AFC is an abbreviation that may refer to:
Amsterdamsche Football Club Ajax (Dutch pronunciation: [ˈaːjɑks]), also AFC Ajax, Ajax Amsterdam or simply Ajax, is a Dutch professional football club based in Amsterdam.
AFC Wimbledon is a professional association football club based in Kingston upon Thames, Greater London, England.
The AFC Champions League, commonly known as the Asian Champions League, is an annual continental club football competition organised by the Asian Football Confederation (AFC).
A.F.C. Rushden & Diamonds is an English football club based in Northamptonshire. They played their opening season at Kiln Park, the home of Raunds Town, in 2011–12 and have subsequently shared the Dog & Duck ground with Wellingborough Town since July 2012. The club was formed in July 2011 by supporters after Rushden & Diamonds, a former Football League club, were expelled from the Football Conference and liquidated.
The AFC Challenge Cup was an international football competition for Asian Football Confederation (AFC) member countries that was categorized as "emerging countries" in the "Vision Asia" programme.
The AFC Championship Game (also unofficially referred to as the AFC Title Game) is one of the two semi-final playoff games of the National Football League (NFL), the largest professional American football league in the United States.
AFC Ajax is one of the most successful football clubs in Europe. There are only three clubs in the history of the game to have won the European Cup/Champions League titles (won four times by Ajax) three times consecutively.
Athletic Football Club Eskilstuna, also known simply as AFC Eskilstuna, is a Swedish football club located in Eskilstuna.
The AFC Asian Cup is an international association football tournament run by the Asian Football Confederation (AFC).