AFO may refer to:
Afonso de Albuquerque, Duke of Goa (Portuguese pronunciation: [ɐˈfõsu dɨ aɫbuˈkɛɾk(ɨ)]; c. 1453–16 December 1515) (also spelled Aphonso or Alfonso), was a Portuguese general, a "great conqueror", a statesman, and an empire builder.
Afotobo (also spelled Affotobo) is a village in central Ivory Coast. It is in the sub-prefecture of Béoumi, Béoumi Department, Gbêkê Region, Vallée du Bandama District.
Afonso I (25 July 1109 – 6 December 1185), nicknamed "the Conqueror" (Portuguese: O Conquistador), "the Founder" (O Fundador) or "the Great" (O Grande) by the Portuguese, and El-Bortukali [in Arabic البرتغال] ("the Portuguese") and Ibn-Arrik [in Arabic ابن الرَّنك or ابن الرَنْق] ("son of Henry", "Henriques") by the Moors whom he fought, was the first King of Portugal.
Afonso Alves Martins Júnior (born 30 January 1981), known as simply Afonso Alves, is a former Brazilian footballer who played as a striker.
Afonso Miguel Castro Vilhena Taira (born 17 June 1992) is a Portuguese footballer who plays for G.D. Estoril Praia as a defensive midfielder.
Afonso Bezerra is a municipality in the state of Rio Grande do Norte in the Northeast region of Brazil.
Aforia crebristriata is a species of sea snail, a marine gastropod mollusk in the family Cochlespiridae.
The Afon Clun is a 14-mile (23 km) long tributary of the River Ely (Welsh: Afon Elai), in the counties of Cardiff and Rhondda Cynon Taf, Wales.
The Afon Clarach (English: River Clarach) is a small river discharging into Cardigan Bay north of Aberystwyth.