CLS may refer to:
CLSCs (centre local de services communautaires, local community service centre) in Quebec are free clinics which are run and maintained by the provincial government.
In particle physics, CLs represent a statistical method for setting upper limits (also called exclusion limits) on model parameters, a particular form of interval estimation used for parameters that can take only non-negative values.
CLS Knights Surabaya is a basketball club based in Surabaya, East Java, Indonesia that plays in the Indonesian Basketball League.
CLSA Ltd. (formally Credit Lyonnais Securities Asia) is a brokerage and investment firm focused on institutional brokerage, investment banking and asset management for corporate and institutional clients around the world.
Claspin is a protein that in humans is encoded by the CLSPN gene.
Calsyntenin-1 is a protein that in humans is encoded by the CLSTN1 gene.
Commonwealth Lightship 4 (CLS4) Carpentaria is a lightship that was in service from 1917 to 1985 with the Commonwealth Lighthouse Service, built at the Cockatoo Island Dockyard and commissioned in 1917. The vessel is named after the Gulf of Carpentaria, where it spent most of its service life together with its sister ship CLS2 (also named Carpentaria).
CLS Communication is a language translation, editing and writing services company based in Switzerland.
CLS (originally Continuous Linked Settlement) is a specialist US financial institution that provides settlement services to its members in the foreign exchange market (FX).