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Amoxicillin/clavulanic acid

The meaning of «amoxicillin/clavulanic acid»

Amoxicillin/clavulanic acid, also known as co-amoxiclav or amox-clav, is an antibiotic medication used for the treatment of a number of bacterial infections.[3] It is a combination consisting of amoxicillin, a β-lactam antibiotic, and potassium clavulanate, a β-lactamase inhibitor.[3] It is specifically used for otitis media, streptococcal pharyngitis, pneumonia, cellulitis, urinary tract infections, and animal bites.[3] It is taken by mouth or by injection into a vein.[2]

Common side effects include diarrhea, vomiting, and allergic reactions.[3] It also increases the risk of yeast infections, headaches, and blood clotting problems.[2][4] It is not recommended in people with a history of a penicillin allergy.[2] It is relatively safe for use during pregnancy.[3]

Amoxicillin/clavulanic acid was approved for medical use in the United States in 1984.[3] It is on the World Health Organization's List of Essential Medicines.[5] The World Health Organization classifies amoxicillin/clavulanic-acid as critically important for human medicine.[6] It is available as a generic medication.[3] In 2019, it was the 93rd most commonly prescribed medication in the United States, with more than 8 million prescriptions.[7][8]

Amoxicillin/clavulanic acid is widely used to treat or prevent many infections caused by susceptible bacteria, such as:

It is also used for tuberculosis that is resistant to other treatments.[3]World health organisation recommends giving amoxicillin-clavulanate along with meropenem as one of the therapeutic options in drug resistant tuberculosis, where clavulanate and not amoxicillin is being relied upon for anti TB activity. However, across the spectrum of dosage of amoxicillin-clavulanate combination, the dose of clavulanate is constant at 125 mg, whereas the dose of amoxicillin varies at 250 mg, 500 mg and 875 mg. Thus the use of low dose amoxicillin-clavulanate in combination with meropenem may be used in part of treatment regime for drug resistant TB & this has been demonstrated in a clinical setting also.[11]

This combination results in an antibiotic with an increased spectrum of action and restored efficacy against amoxicillin-resistant bacteria that produce β-lactamase.[citation needed]

Possible side effects include diarrhea, vomiting, nausea, thrush, and skin rash. These do not usually require medical attention. As with all antimicrobial agents, antibiotic-associated diarrhea due to Clostridium difficile infection—sometimes leading to pseudomembranous colitis—may occur during or after treatment with amoxicillin/clavulanic acid.[10]

Rarely, cholestatic jaundice (also referred to as cholestatic hepatitis, a form of liver toxicity) has been associated with amoxicillin/clavulanic acid. The reaction may occur up to several weeks after treatment has stopped, and usually takes weeks to resolve. It is more frequent in men, older people, and those who have taken long courses of treatment; the estimated overall incidence is one in 100,000 exposures.[10] In the United Kingdom, co-amoxiclav carries a warning from the Committee on Safety of Medicines to this effect.[9]

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