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Snd1

The meaning of «snd1»

2E6N, 2HQE, 2HQX, 2O4X, 3BDL, 3OMC, 3OMG, 4QMG

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene.[5][6][7][8] SND1 is a main component of RISC complex[9] and plays an important role in miRNA function.[10][11] SND1 is Tudor domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster.[12] SND1 is also involved in Autism.[13]

SND1 acts as oncogene in many cancers[14][15][16] and in hepatocellular carcinoma progression.[10][11] SND1 promotes tumor angiogenesis in human hepatocellular carcinoma through a novel pathway which involves NF-kappaB and miR-221.[17] SND1 promotes migration and invasion via angiotensin II type 1 receptor and TGFβ signaling.[18] SND1 expression is regulated by Mir-184 in gliomas.[19]

SND1 has been shown to interact with MYB,[20]

SND1 also interacts with G3BP (stress granule protein)[25] and AEG-1.[10][11]

2hqx: Crystal structure of human P100 tudor domain conserved region

2o4x: Crystal structure of human P100 tudor domain

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