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Tfcp2

The meaning of «tfcp2»

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.[5][6]

TFCP2 is also called Late SV40 factor (LSF) and it is induced by well known oncogene AEG-1.[7] Late SV40 factor (LSF) also acts as an oncogene in hepatocellular carcinoma.[8] Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).[9]

Along with its main oncogene function in hepatocellular carcinoma (HCC) it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease.[8][10] The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding to HCC DNA which results in HCC cell death.[8][10][11]

TFCP2 has been shown to interact with APBB1[12] and RNF2.[13]

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