AFL may refer to:
The AFL Grand Final is an annual Australian rules football match, traditionally held on the final Saturday in September or the first Saturday in October at the Melbourne Cricket Ground in Melbourne, Australia, to determine the Australian Football League (AFL) premiers for that year.
The American Federation of Labor and Congress of Industrial Organizations (AFL–CIO) is a national trade union center and the largest federation of unions in the United States.
The AFL–NFL merger was the merger of the two major professional American football leagues in the United States at the time: the National Football League (NFL) and the American Football League (AFL).
AFL Women's (AFLW) is the national professional Australian rules football league for female players. The first season of the league began in February 2017 with eight teams.
Aflatoxins are poisonous and cancer-causing chemicals that are produced by certain molds (Aspergillus flavus and Aspergillus parasiticus) which grow in soil, decaying vegetation, hay, and grains.
The AFL siren controversy (dubbed Sirengate) surrounded the conclusion and result of an Australian rules football match played on 30 April 2006 during Round 5 of the Australian Football League's 2006 season.