AFS is an acronym that may refer to:
AFS Intercultural Programs (or AFS, originally the American Field Service) is an international youth exchange organization.
Afshin Ghotbi (Persian: افشین قطبی, born 8 February 1964 in Tehran, Iran) is an Iranian American football coach.
The Afshar experiment is an optics experiment, devised and carried out by Shahriar Afshar at Harvard University in 2004, which is a variation of the double slit experiment in quantum mechanics.
Afshan Azad (born 12 February 1988) is an English actress and model of Bangladeshi descent. She is best known for playing the role of Padma Patil in the Harry Potter film series, except for Harry Potter and the prisoner of Azkaban, which was portrayed by Sharon Sandhu.
AFSCME Council 31 is the Illinois state chapter of the American Federation of State, County and Municipal Employees (AFSCME), a union of public service workers in the public, private and non-profit sectors.