CLO may refer to:
Cloak (Tyrone "Ty" Johnson) and Dagger (Tandy Bowen) are a fictional comic book superhero duo appearing in American comic books published by Marvel Comics.
Cloud computing is a type of Internet-based computing that provides shared computer processing resources and data to computers and other devices on demand.
Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia.
Clostridium difficile infection (CDI) is a symptomatic infection due to the spore-forming bacterium, Clostridium difficile.
Closed-circuit television (CCTV), also known as video surveillance, is the use of video cameras to transmit a signal to a specific place, on a limited set of monitors.
Clothing (also called clothes and attire) is fiber and textile material worn on the body. The wearing of clothing is mostly restricted to human beings and is a feature of nearly all human societies.
A clock is an instrument to measure, keep, and indicate time. The word clock is derived (via Dutch, Northern French, and Medieval Latin) from the Celtic words clagan and clocca meaning "bell".