COE or Coe may refer to:

Coeliac disease, also spelled celiac disease, is a long term autoimmune disorder primarily affecting the small intestine that occurs in people who are genetically predisposed.

Joel David Coen (born November 29, 1954) and Ethan Jesse Coen (born September 21, 1957), collectively referred to as the Coen brothers, are American filmmakers.

Coenzyme Q10, also known as ubiquinone, ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10 , CoQ, or Q10 is a coenzyme that is ubiquitous in animals and most bacteria (hence the name ubiquinone).

Coeur d'Alene ( KOHR də-LAYN) is the largest city and county seat of Kootenai County, Idaho, United States.

In statistics, the coefficient of determination, denoted R2 or r2 and pronounced "R squared", is the proportion of the variance in the dependent variable that is predictable from the independent variable(s).

In probability theory and statistics, the coefficient of variation (CV), also known as relative standard deviation (RSD), is a standardized measure of dispersion of a probability distribution or frequency distribution.

In biology, coevolution occurs when two or more species reciprocally affect each other's evolution.