OF or Of may refer to:
Office Space is a 1999 American comedy film written and directed by Mike Judge. It satirizes the everyday work life of a typical mid-to-late-1990s software company, focusing on a handful of individuals fed up with their jobs.
An officer is a member of an armed forces or uniformed service who holds a position of authority.
Office 365 is a line of subscription services offered by Microsoft as part of the Microsoft Office product line.
An Offshore Financial Centre or OFC is defined as a country or jurisdiction that provides financial services to nonresidents on a scale that is incommensurate with the size and the financing of its domestic economy.
In American football, an official is a person who has responsibility in enforcing the rules and maintaining the order of the game.
Offal (), also called variety meats, pluck or organ meats, is the viscera (internal organs) and entrails of a butchered animal.
Of Mice and Men is a novella written by John Steinbeck. Published in 1937, it tells the story of George Milton and Lennie Small, two displaced migrant ranch workers, who move from place to place in California in search of new job opportunities during the Great Depression in the United States.