TL or Tl may refer to:
TLC (originally an initialism for The Learning Channel) is an American basic cable and satellite television network that is owned by Discovery, Inc.
"Tlön, Uqbar, Orbis Tertius" is a short story by the 20th-century Argentine writer Jorge Luis Borges. The story was first published in the Argentine journal Sur, May 1940. The "postscript" dated 1947 is intended to be anachronistic, set seven years in the future.
Tlalpan ( modern Nahuatl pronunciation ) is one of the 16 administrative boroughs (called delegaciones in Spanish) of the Federal District of Mexico City.
Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family.
The Tlingit language (; Lingít [ɬìnkít]) is spoken by the Tlingit people of Southeast Alaska and Western Canada.