TL or Tl may refer to:
TLC (originally an initialism for The Learning Channel) is an American pay television channel that is owned by Discovery, Inc.
"Tlön, Uqbar, Orbis Tertius" is a short story by the 20th-century Argentine writer Jorge Luis Borges. The story was first published in the Argentine journal Sur, May 1940. The "postscript" dated 1947 is intended to be anachronistic, set seven years in the future.
Tlalpan (modern Nahuatl pronunciation ) is one of the 16 administrative boroughs (called alcaldías in Spanish) of Mexico City.
The Tlingit language (; Lingít [ɬìnkítʰ]) is spoken by the Tlingit people of Southeast Alaska and Western Canada and is a branch of the Na-Dene language family.
Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family.