VC may refer to:
vCard, also known as VCF (Virtual Contact File), is a file format standard for electronic business cards.
Voice of Christian Youth America, a.k.a. VCY America, is a traditional, evangelical Christian ministry based in Milwaukee, Wisconsin.
VCE (abbreviation for "Virtual Computing Environment") was a division of EMC Corporation that manufactured converged infrastructure appliances for enterprise environments.
SMPTE 421M, informally known as VC-1, is a video coding format. Most of it was initially developed as the proprietary video format Windows Media Video 9 by Microsoft in 2003. With some enhancements including the development of a new Advanced Profile, it was officially approved as a SMPTE video codec standard on April 3, 2006.