Zo or ZO may refer to:
Zoroastrianism, or more natively Mazdayasna, is one of the world's oldest religions that remains active.
Zolpidem, sold under the brand name Ambien, among others, is a sedative primarily used for the treatment of sleeping problems.
Zootopia is a 2016 American 3D computer-animated buddy cop comedy film produced by Walt Disney Animation Studios and released by Walt Disney Pictures.
A zombie (Haitian French: zombi, Haitian Creole: zonbi) is a fictional undead being created through the reanimation of a human corpse.
Zombieland is a 2009 American post-apocalyptic horror comedy film directed by Ruben Fleischer and written by Rhett Reese and Paul Wernick.
Zopiclone (brand names Imovane, Zimovane, and Dopareel) is a nonbenzodiazepine hypnotic agent used in the treatment of insomnia.